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Inside this poster
See screening data, compound validation, and functional assay results from a 892-compound HTS campaign in hiPSC-derived microglia built on Ricoh Biosciences' Quick-Microglia™ SeV platfo
- A primary screen of 892 FDA-approved compounds at 10 µM identified 11 candidates with z-scores above 2.0, with nearly all sharing a structurally similar functional group, supporting reproducibility of the screen.
- Secondary PrestoBlue validation of 5 shortlisted compounds at Day 7 and Day 21 confirmed Compound X as the highest-viability hit across both short-term and long-term culture periods.
- Treatment with Compound X significantly increased pHrodo fluorescence signal in MG-SeV cultures (RFU 13 ± 2.4 vs. 2.3 ± 0.81 for DMSO control), demonstrating improved phagocytic functional capacity.
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