Using ALS Patient-Derived Motor Neurons to Study TDP-43 Mislocalization

Join our upcoming webinar to learn how TDP-43 mislocalization is reproduced in patient-derived ALS motor neuron models and used to evaluate drug responses.

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Our Platform

We start with the endpoint in mind: a transcriptional and functional signature of your desired mature cell type. Using bulk and single-cell RNA-seq data from trusted, publicly available datasets, we establish a transcriptomic benchmark that includes:

Lineage-defining markers
Functionally relevant genes
Developmental and subtype-specific regulators

This target phenotype serves as a quantitative standard for evaluating differentiation fidelity—ensuring that cells don’t just look right, but act right.

Gene expression alone is not enough. We refine culture conditions to support:

Maturation of physiological properties
Subtype specification and stability
Functional competence validated via phenotypic markers and assays

Using defined media, small molecules, and timed induction strategies, our protocols are optimized for robustness across multiple donors and lots—minimizing variability and ensuring translational relevance.

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Services

Get your studies off the ground fast with Ricoh Biosciences’ services using iPSCs and iPSC-derived cells tailored to your research requirements. Our transcription factor-based proprietary technology enables iPSC differentiation with a fast turnaround time to accelerate your research.

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New Cell Type Development

Novel cell types made for your unique research.

Custom iPSC Differentiation

iPSC-derived cells tailored for your exact needs.

Disease Modeling

Patient-specific cells for modeling complex diseases.

Our Products

iPSC-based solutions designed for your research.

From rapid differentiation kits to custom-developed human cell types, our products are engineered to accelerate discovery and reduce time to insight—whether you’re modeling disease, screening compounds, or developing cell-based assays.

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Excitatory Neurons

The Ricoh Biosciences Difference

Generate specialized human cells in just 1-2 weeks with our flexible iPSC/ESC differentiation solutions. Our simple workflows let any lab create diverse cell types, and our technology produces functional models that scale easily for high-content screening.

Fast

Use our kits or use our service to generate differentiated cell and tissue types from human iPSCs and ESCs in just 1-2 weeks.

Flexible

Our workflows mean any lab can easily differentiate any iPS or ES cell line, expanding the options for cell type, disease state, and genetic background.

Functional

Ricoh Biosciences’ iPSC differentiation technology produces functional and more physiologically relevant cell-based models that better represent human biology.

Scalable

Produce virtually limitless amounts of identical human cells with our quick and easy differentiation technology—ideal for high content screening applications.

Educational Resources

Empower Yourself with Knowledge

The team at Ricoh Biosciences is commited to your success. If you don’t find protocol, publication, or answer to your question in our Educational Resources section, feel free to contact us.

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