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Review genetic characterization, electrophysiological validation, and MEA-based drug response data for Quick-Neuron™ Excitatory Neurons in long-term coculture with primary human astrocytes.
- RNA-seq and PCA demonstrating that Quick-Neuron™ Excitatory Neurons cocultured with primary astrocytes for 52 days achieve gene expression profiles highly similar to adult human brain
- Whole-cell patch clamp at 5-6 weeks post-thaw confirming spontaneous action potentials and excitatory postsynaptic currents at -70 mV, indicating formation of mature synapses
- MEA drug response data across 15 compounds spanning receptor agonists, antagonists, and ion channel blockers in 51-day cocultures, with expected responses confirmed for each compound and preserved activity after a 33-hour international transport
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