Log in
Change Country/Area Ricoh Biosciences, Inc.
Poster

Using Human iPSC-Derived Neurons and Astrocytes Produced by Transcription Factor-Based Differentiation Protocols to Generate Models to Study Alzheimer’s Disease In Vitro

Human iPSC-derived excitatory neurons and astrocytes, generated by transcription factor-based differentiation, model Alzheimer's disease phenotypes for drug discovery research.

Talk to Our Team Download the Poster

Download Your Poster

Cover of the CNS ipsc-derived cell characterization application note

"*" indicates required fields

agree check

We respect your inbox. You can unsubscribe at any time. View our privacy policy.

Inside This Poster

Review a transcription factor-based iPSC differentiation platform used to model Alzheimer's disease phenotypes in neurons and astrocytes.

  • iPSC-derived excitatory neurons from an Alzheimer's patient line showed elevated Tau and amyloid-beta levels compared to a healthy donor line.
  • Astrocytes derived from an Alzheimer's patient iPSC line showed a greater tendency toward a fibroblast-like morphology than healthy donor-derived astrocytes.
  • Treatment with BACE1 inhibitor compounds reduced amyloid-beta peptide production in Alzheimer's patient-derived neurons, as expected.