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Poster

Establishment of High-Throughput Toxicity Assay System with iPSC-derived GABAergic Neurons Generated by a Rapid Differentiation Method

A high-throughput calcium imaging assay using rapidly differentiated iPSC-derived GABAergic neurons in 3D spheroid coculture to evaluate seizurogenic compound responses in 384-well format.

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Inside This Poster

Explore how a rapid, transcription factor-based differentiation method generates iPSC-derived GABAergic neurons suited for high-throughput toxicity screening of seizurogenic compounds in a 384-well plate format.

  • iPSC-derived GABAergic neurons release GABA and form functional GABAergic synapses in culture.
  • The GABAergic neurons generally responded as expected to seizurogenic compounds, particularly when co-cultured with iPSC-derived astrocytes.
  • The assay system is adaptable for high-throughput screening in 384-well plates.