Log in
Change Country/Area Ricoh Biosciences, Inc.
Poster

Generation of an Alzheimer’s Disease Model Using Human iPSC-Derived Neurons and Astrocytes Produced by a Transcription Factor-Based Differentiation Protocol

A transcription factor-based iPSC differentiation platform generates human excitatory neurons and astrocytes that model Alzheimer's disease phenotypes for drug discovery and pharmacological testing.

Talk to Our Team Download the Poster

Download Your Poster

Cover of the CNS ipsc-derived cell characterization application note

"*" indicates required fields

agree check

We respect your inbox. You can unsubscribe at any time. View our privacy policy.

Inside This Poster

Explore a transcription factor-based iPSC differentiation platform that generates human excitatory neurons and astrocytes and examine how Alzheimer's disease patient-derived cells differ from healthy donor cells.

  • A transcription factor-based protocol differentiates human iPSCs into excitatory neurons in 10 days and astrocytes in 28 days, confirmed by marker expression and morphology.
  • iPSC-derived neurons from an Alzheimer's disease patient showed higher amyloid beta and tau protein levels than healthy donor neurons, with reduced amyloid beta after beta secretase inhibitor treatment.
  • Astrocytes derived from an Alzheimer's disease patient iPSC line showed a fibroblast-like morphology more often than astrocytes from a healthy control line.